Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes


In the face of vaccine dose shortages and logistical challenges, various deployment strategies are being proposed to increase population immunity levels to SARS-CoV-2. How timing of delivery of the second dose affects infection burden but also prospects for the evolution of viral immune escape via a build-up of partially immune individuals are critical questions. Both hinge on the robustness of the immune response elicited by a single dose, compared to natural and two-dose immunity. Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. We then explore three scenarios of selection and find that a one-dose policy may increase the potential for antigenic evolution under certain conditions. We highlight the critical need to test viral loads and quantify immune responses after one vaccine dose, and to ramp up vaccination efforts throughout the world.

The interactive shiny app I created for this paper can be found here.